Title(s): Professor Emeritus, Microbiology and Immunology
School: School of Medicine
Address: 513 Parnassus Avenue, HSE-201
San Francisco, CA 94143-0414
Phone Number: (415)476-5451
Email: jeoung-sook.shin@ucsf.edu
Overview
Jeoung-Sook Shin is an Associate Professor in the Department of Microbiology & Immunology. She completed her B.S. and M.S. in Chemistry at Seoul National University, Korea. She received her Ph.D. from Duke University and her postdoctoral training at Yale University as a Jane Coffin Childs Memorial Fund Postdoctoral Fellow.
The Shin laboratory is interested in understanding the molecular mechanisms by which dendritic cells shape and control T cell immunity. The current research is focused on understanding the role of a membrane-anchored ubiquitin ligase named MARCH1 (membrane-associated RINCCH1). MARCH1 is highly expressed in dendritic cells, attaches ubiquitin chains to the cytoplasmic tail of MHCII, CD86, and possibly other membrane proteins, and mediates endocytosis, lysosomal sorting, and degradation of the substrates. Through this activity, MARCH1 promotes surface turnover of specific immune-associated molecules in dendritic cells. However, its functional role is not clearly understood.